Amelioration of cancer cachexia with preemptive administration of tumor necrosis factor-α blocker
Volume: 70, Issue: 2, Pages: 117 - 128
Published: Jan 1, 2022
Abstract
Cancer cachexia is syndrome accompanying weight reduction, fat loss, muscle atrophy in patients with advanced cancer. Since tumor necrosis factor-α (TNF-α) played pivotal role in cancer cachexia, we hypothesized preemptive administration of TNF-α antibody might mitigate cancer cachexia. Detailed molecular mechanisms targeting muscle atrophy, cachexic inflammation, and catabolic catastrophe were explored whether TNF-α antibody can antagonize...
Paper Details
Title
Amelioration of cancer cachexia with preemptive administration of tumor necrosis factor-α blocker
Published Date
Jan 1, 2022
Volume
70
Issue
2
Pages
117 - 128
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