Copper-Catalyzed Intermolecular Alkynylation and Allylation of Unactivated C(sp3)–H Bonds via Hydrogen Atom Transfer
Abstract
We describe Cu-catalyzed intermolecular alkynylation and allylation of unactivated C(sp3)-H bonds with singly occupied molecular orbital-philes (SOMO-philes) via hydrogen atom transfer (HAT). Employing N-fluoro-sulfonamide as a HAT reagent, a set of substituted alkene and alkyne compounds were synthesized in high yields with good regioselectivity and functional-group compatibility. Late-stage functionalization of natural products and drug...
Paper Details
Title
Copper-Catalyzed Intermolecular Alkynylation and Allylation of Unactivated C(sp3)–H Bonds via Hydrogen Atom Transfer
Published Date
Oct 20, 2021
Journal
Volume
23
Issue
21
Pages
8575 - 8579
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