VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives

Volume: 227, Pages: 113906 - 113906
Published: Jan 1, 2022
Abstract
Proteolysis targeting chimeras (PROTACs), which hijack proteins of interest (POIs) and recruit E3 ligases for target degradation via the ubiquitin-proteasome pathway, are a novel drug discovery paradigm that has been widely used as biological tools and medicinal molecules with the potential of clinical application value. To date, a wide variety of small molecule PROTACs have been developed. Importantly, VHL-based PROTACs have emerged to be a...
Paper Details
Title
VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives
Published Date
Jan 1, 2022
Volume
227
Pages
113906 - 113906
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