A robust method for the assessment of average bioequivalence in the presence of outliers and skewness

In this paper, we propose a robust Bayesian method for the assessment of average bioequivalence based on data from conventional crossover studies. We evaluate and motivate empirically the need for robust methods in bioequivalence studies by comparing the results of robust and conventional statistical methods in a large data pool of bioequivalence studies. Robustness of the statistical methodology is achieved by replacing the normal distributions...