Polygenic burden could explain high rates of affective disorders in a community with restricted founder population.

Volume: 186, Issue: 6, Pages: 367 - 375
Published: Sep 1, 2021
Abstract
This study investigates if genetic factors could contribute to the high rate of mood disorders reported in a U.S. community known to have a restricted early founder population (confirmed here through runs of homozygosity analysis). Polygenic scores (PGSs) for eight common diseases, disorders, or traits, including psychiatric disorders, were calculated in 274 participants (125 mood disorder cases) who each reported three or four grandparents born...
Paper Details
Title
Polygenic burden could explain high rates of affective disorders in a community with restricted founder population.
Published Date
Sep 1, 2021
Volume
186
Issue
6
Pages
367 - 375
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