1795P Gender difference in side effects of immunotherapy: A possible clue to optimize cancer treatment

The use of immunotherapy to treat cancer patients can induce immune-related adverse events (irAEs) caused by non-specific activation of the immune system. Patient’s sex can influence adaptive immunity and, in turn, irAEs incidence, type and severity. We are undertaking a multicenter observational prospective study to investigate irAEs incidence, and female (F)/male (M) inequalities linked to sex (genetic and biological characteristics) and...