Engineering a genome‐reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
Abstract
Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated bacterial infections. This strain has a unique genetic code, which hinders gene transfer to most other bacterial genera, and it lacks a cell wall, which allows it to express proteins that target peptidoglycans of pathogenic bacteria. We...
Paper Details
Title
Engineering a genome‐reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
Published Date
Oct 1, 2021
Journal
Volume
17
Issue
10
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