Photoperiodic modulation of ovarian metabolic, survival, proliferation and gap junction markers in adult golden hamster, Mesocricetus auratus.

Published on Jan 1, 2022in Comparative Biochemistry and Physiology A-molecular & Integrative Physiology2.32
· DOI :10.1016/J.CBPA.2021.111083
Sriparna Pal1
Estimated H-index: 1
(BHU: Banaras Hindu University),
Chandana Haldar24
Estimated H-index: 24
(BHU: Banaras Hindu University),
Rakesh Verma4
Estimated H-index: 4
(BHU: Banaras Hindu University)
Sources
Abstract
Female reproductive physiology is greatly dependent on tight regulation of metabolic and survival factors. Photoperiod regulates female reproductive rhythms but very less information exists explaining whether photoperiod could modulate thyroid hormone homeostasis, metabolic/energy parameters along with survival, proliferation and gap junction proteins in the ovary of a long-day breeder, Mesocricetus auratus. Adult female hamsters were exposed to different photoperiodic regimes i.e., critical photoperiod (CP; 12.5L:11.5D), short photoperiod (SP; 8L:16D) and long photoperiod (LP; 16L:8D) for 12 weeks. LP upregulated thyroidal and gonadal activity as apparent by histoarchitecture, thyroid hormone profile [triiodothyronine (T3), thyroxin (T4) and thyroid stimulating hormone (TSH)], luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2) and progesterone (P4) levels when compared with SP exposed hamsters. Further, LP increased thyroid hormone receptor-α/deiodinase-2 (TRα/Dio-2), estrogen receptor-α (ERα)/aromatase and insulin receptor/glucose transporter-4 (IR/GLUT-4) expressions in ovary. Interestingly, ovarian sirtuin-1 (SIRT-1) expression was also upregulated under LP condition along with cell proliferation (proliferating cell nuclear antigen or PCNA), survival (B cell lymphoma-2 or Bcl-2) and gap junction (connexin-43) markers when compared to SP exposed hamsters. We also noted elevated levels of circulatory leptin, insulin along with melatonin and its receptor (MT-1) in ovary under SP condition. Thus, we suggest that photoperiod plays a vital role in regulation of thyroid and reproductive hormone homeostasis along with key metabolic and survival markers in the ovary of adult golden hamsters, M. auratus providing further insight into the regulation of female reproductive seasonality in a long-day breeder.
References62
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#1Shruti R. Hansda (BHU: Banaras Hindu University)H-Index: 1
#2Chandana Haldar (BHU: Banaras Hindu University)H-Index: 24
Abstract null null Aims null Polycystic ovarian syndrome (PCOS) is a reproductive, endocrine and metabolic disorder. Less is known about the mechanism of its effect on uterine function and therapeutic potential of melatonin. Our aim was to evaluate uterine dysfunction(s) in letrozole induced PCOS and its possible rectification by melatonin. null null null Main methods null Adult female golden hamsters were divided into groups of Control (C), Melatonin (M; 1 mg/kg b.w.), Letrozole (L; 3 mg/kg b.w...
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#1Jitendra Kumar (BHU: Banaras Hindu University)H-Index: 35
#2Rakesh Verma (BHU: Banaras Hindu University)H-Index: 4
Last. Chandana Haldar (BHU: Banaras Hindu University)H-Index: 24
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BPS has detrimental effects on human reproductive health and emerged as an environmental contaminant for global health concern. This study deals with the adverse impact of BPS exposure on testicular oxidative stress, inflammation and apoptosis in adult male golden hamster, Mesocricetus auratus and its amelioration by melatonin. BPS (75 mg/kg BW/day) exposure caused testicular impairment as evident by histological degenerative changes, declined sperm quality (viability and motility), serum levels...
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#1Jitendra Kumar (BHU: Banaras Hindu University)H-Index: 35
#2Chandana Haldar (BHU: Banaras Hindu University)H-Index: 24
Last. Rakesh Verma (BHU: Banaras Hindu University)H-Index: 4
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The excess fluoride intake has been shown to adversely affect male reproductive health. The aim of the present study was to investigate the key mechanism underlying fluoride-induced testicular dysfunction and the role of melatonin as a modulator of testicular metabolic, oxidative, and inflammatory load. The present results indicated that sodium fluoride (NaF) exposure to adult male golden hamsters severely impairs reproductive physiology as evident from markedly reduced sperm count/viability, te...
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#1Sriparna Pal (BHU: Banaras Hindu University)H-Index: 1
#2Rakesh Verma (BHU: Banaras Hindu University)H-Index: 4
Last. Chandana Haldar (BHU: Banaras Hindu University)H-Index: 24
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ABSTRACTThe environmental photoperiod plays an important role in regulation of seasonal reproductive events. However, with reference tooestrogen status the exact mechanism involved in testicular seasonality is still unclear in general and especially in long-day breeder golden hamster, Mesocricetus auratus. Therefore, in the present study we explored the effect of day length (long day, LD and short day, SD) in modulation of oestrogen level, metabolic and gap junction markers expressionin testes. ...
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#1Jayita Pal Chowdhury (BHU: Banaras Hindu University)H-Index: 2
#2Chandana Haldar (BHU: Banaras Hindu University)H-Index: 24
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#1Cristina Luongo (University of Naples Federico II)H-Index: 11
#2Monica Dentice (University of Naples Federico II)H-Index: 27
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The deiodinase family of enzymes mediates the activation and inactivation of thyroid hormone. The role of these enzymes in the regulation of the systemic concentrations of thyroid hormone is well established and underpins the treatment of common thyroid diseases. Interest in this field has increased in the past 10 years as the deiodinases became implicated in tissue development and homeostasis, as well as in the pathogenesis of a wide range of human diseases. Three deiodinases have been identifi...
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#1Dake Zhao (Yunnan University)H-Index: 8
#2Yang Yu (Yunnan University)H-Index: 3
Last. Russel J. Reiter (University of Texas Health Science Center at San Antonio)H-Index: 200
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Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin’s initial function was likely that as a free radical scavenger. Melatonin presumably evolved in bacteria; it has been measured in both α-proteobacteria and in photosynthetic cyanobacteria. In early evolution, bacteria were phagocytosed by primitive eukaryotes for their nutrient value. According to the endosymbiontic theory, the ingested bacteria eventually developed a symbiotic association with their host e...
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#1Longfei Xiao (GAU: Gansu Agricultural University)H-Index: 5
#2Junjie Hu (GAU: Gansu Agricultural University)H-Index: 6
Last. Xingxu Zhao (GAU: Gansu Agricultural University)H-Index: 9
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Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep cumulus–oocyte complexes (COCs) as well as the change of melatonin level in follicular fluid (FF) during antral follicle development. In this research, we also study the effect of β-estradiol (E2) on MT1 and MT2 expression as well as melatonin s...
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Abstract Visfatin is an adipokine which has an endocrine effect on reproductive functions and regulates ovarian steroidogenesis. There is scant information about the expression, regulation, and functions of visfatin in the mammalian uterus. The present study examined expression and localization of visfatin in the mouse uterus at various stages of the natural estrous cycle, effects of estrogen and progesterone on localization and expression of visfatin in the ovariectomised mouse uterus and effec...
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#1Pierre Gourdy (French Institute of Health and Medical Research)H-Index: 43
#2Maeva Guillaume (French Institute of Health and Medical Research)H-Index: 12
Last. Jean-François Arnal (French Institute of Health and Medical Research)H-Index: 60
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Abstract Background In addition to their crucial role in reproduction, estrogens are key regulators of energy and glucose homeostasis and they also exert several cardiovascular protective effects. These beneficial actions are mainly mediated by estrogen receptor alpha (ERα), which is widely expressed in metabolic and vascular tissues. As a member of the nuclear receptor superfamily, ERα was primarily considered as a transcription factor that controls gene expression through the activation of its...
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