Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates
Abstract
In antibody-drug conjugates (ADCs), monoclonal antibodies (mAbs) act as carriers for a cytotoxic payload providing the therapy with targeted action against cells expressing a target cell surface antigen. An appropriate choice of mAb is crucial to developing a successful ADC for clinical development. However, problems such as immunogenicity, poor pharmacokinetic (PK) and pharmacodynamic (PD) profiles and variable drug-antibody ratios (DARs)...
Paper Details
Title
Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates
Published Date
Jan 1, 2022
Journal
Volume
27
Issue
1
Pages
354 - 361
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