Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation

Volume: 35, Issue: 19-20, Pages: 1325 - 1326
Published: Oct 1, 2021
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Virtually all PDAC harbors an oncogenic mutation in the KRAS gene, making it the prime target for therapy. Most previous attempts to inhibit KRAS directly have been disappointing, but recent success in targeting some KRAS mutants presages a new era in PDAC therapy. Models of PDAC have predicted that identifying KRAS inhibitor resistance mechanisms will be critical. In this...
Paper Details
Title
Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation
Published Date
Oct 1, 2021
Volume
35
Issue
19-20
Pages
1325 - 1326
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