T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese

Abstract
Cellular ionic concentrations are a central factor orchestrating host innate immunity, but no pathogenic mechanism that perturbs host innate immunity by directly targeting metal ions has yet been described. Here, we report a unique virulence strategy of Yersinia pseudotuberculosis (Yptb) involving modulation of the availability of Mn2+, an immunostimulatory metal ion in host cells. We showed that the Yptb type VI secretion system (T6SS)...
Paper Details
Title
T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese
Published Date
Oct 8, 2021
Volume
118
Issue
42
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