Spock2 is mainly produced in pancreatic stellate cells and hypermethylated in pancreatic cancer cell lines

Background and aims SPOCK2, Sparc/Osteonection, cwcv, and kazal-like domains proteoglycan2, also called testican-2, is a member of the SPARC family. This gene encodes a protein, which can bind to glycosaminoglycans to form part of the extracellular matrix, and plays a role in cell adhesion and migration. In cancer, SPOCK2 was reported the first time in prostate, breast, and colon cancer and showed significantly higher methylation in cancer cells...