A force-balance model for centrosome positioning and spindle elongation during Interphase and Anaphase B
Abstract
A computational model in one dimension is proposed to position a single centrosome using astral microtubules (MTs) interacting with the cell cortex. The mechanism exploits mutually antagonistic pulling and pushing forces arising from the astral MTs’ binding to cortical dynein motors in the actin-rich cell cortex and their buckling while growing against the cell cortex, respectively. The underlying mechanism of astral MTs is also extended to...
Paper Details
Title
A force-balance model for centrosome positioning and spindle elongation during Interphase and Anaphase B
Published Date
Oct 4, 2021
Journal
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