Recent developments in chemical conjugation strategies targeting native amino acids in proteins and their applications in antibody–drug conjugates
Abstract
Many fields in chemical biology and synthetic biology require effective bioconjugation methods to achieve their desired functions and activities. Among such biomolecule conjugates, antibody-drug conjugates (ADCs) need a linker that provides a stable linkage between cytotoxic drugs and antibodies, whilst conjugating in a biologically benign, fast and selective fashion. This review focuses on how the development of novel organic synthesis can...
Paper Details
Title
Recent developments in chemical conjugation strategies targeting native amino acids in proteins and their applications in antibody–drug conjugates
Published Date
Jan 1, 2021
Journal
Volume
12
Issue
41
Pages
13613 - 13647
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