Role of Permeability on the Biopredictive Dissolution of Amorphous Solid Dispersions

Volume: 22, Issue: 7
Published: Sep 30, 2021
Abstract
An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect physicochemical, physiological, and hydrodynamic conditions which accurately represent in vivo dissolution. However, this is confounded by the evolution of different molecular and colloidal species during dissolution, generating a supersaturated state of the drug. The supersaturated state of a drug is thermodynamically unstable which drives the process of...
Paper Details
Title
Role of Permeability on the Biopredictive Dissolution of Amorphous Solid Dispersions
Published Date
Sep 30, 2021
Journal
Volume
22
Issue
7
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