491P Lipid-engulfed macrophages at the root of gut carcinogenesis

Definite polarization of tumor associated macrophages (TAMs) sustains tumorigenesis and cancer progression. Dysregulation of lipid metabolism hold a potential role in the acquisition of immunosuppressive phenotype and the overcoming of tumor immune surveillance. The aim of the study was to investigate the crosstalk between dyslipidemic myeloid cells and adaptive immunity in early and late colorectal cancer...