Targeting of the tumor immune microenvironment by metformin

Volume: 16, Issue: 3, Pages: 333 - 348
Published: Oct 5, 2021
Abstract
Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4 + and CD8 + T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor microenvironment (TME). In contrast to these cells, regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and tumor-associated macrophages (TAMs) release several molecules to suppress antitumor immunity...
Paper Details
Title
Targeting of the tumor immune microenvironment by metformin
Published Date
Oct 5, 2021
Volume
16
Issue
3
Pages
333 - 348
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