c-FOS drives reversible basal to squamous cell carcinoma transition
Abstract
While squamous transdifferentiation within subpopulations of adenocarcinomas represents an important drug resistance problem, its underlying mechanism remains poorly understood. Here, using surface markers of resistant basal cell carcinomas (BCCs) and patient single-cell and bulk transcriptomic data, we uncover the dynamic roadmap of basal to squamous cell carcinoma transition (BST). Experimentally induced BST identifies activator protein 1...
Paper Details
Title
c-FOS drives reversible basal to squamous cell carcinoma transition
Published Date
Oct 1, 2021
Journal
Volume
37
Issue
1
Pages
109774 - 109774
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Notes
History