SPOP mutation induces DNA methylation via stabilizing GLP/G9a
Abstract
Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and promotes polyubiquitination and degradation of histone methyltransferase and DNMT interactor GLP. SPOP mutation induces stabilization of GLP and its partner protein G9a and aberrant upregulation of global DNA hypermethylation in...
Paper Details
Title
SPOP mutation induces DNA methylation via stabilizing GLP/G9a
Published Date
Sep 29, 2021
Journal
Volume
12
Issue
1
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