Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Abstract
Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in cancer, often observed independently of genetic heterogeneity, raising the central question of how malignant cell states are encoded epigenetically. To address this, here we performed multiomics single-cell profiling-integrating DNA methylation, transcriptome and genotype within the same cells-of diffuse gliomas, tumors characterized by defined...
Paper Details
Title
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Published Date
Sep 30, 2021
Journal
Volume
53
Issue
10
Pages
1469 - 1479
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History