Use of a Therapeutic Trial of Graduated Neoadjuvant Radiation Therapy for Locally Advanced Esophageal Cancer in a Patient With Fanconi Anemia

Fanconi anemia (FA) is a rare and inherited disorder leading to an inability to repair DNA by homologous recombination.1,2 The product of the FA pathway is DNA stability through interstrand crosslink repair.3 A loss of function in the FA pathway causes cell hypersensitivity to genotoxic stress, results in a loss of hematopoietic stem cells, and increases the predilection to certain...