Liposomal formulations of anticancer copper(ii ) thiosemicarbazone complexes
Abstract
α-N-Heterocyclic thiosemicarbazones such as triapine and COTI-2 are currently investigated as anticancer therapeutics in clinical trials. However, triapine was widely inactive against solid tumor types. A likely explanation is the short plasma half-life time and fast metabolism. One promising approach to overcome these drawbacks is the encapsulation of the drug into nanoparticles (passive drug-targeting). In a previous work we showed that it was...
Paper Details
Title
Liposomal formulations of anticancer copper(ii ) thiosemicarbazone complexes
Published Date
Jan 1, 2021
Journal
Volume
50
Issue
44
Pages
16053 - 16066
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History