The combination of aging and chronic kidney disease leads to an exacerbated cortical porosity phenotype

Chronic kidney disease (CKD) and aging are each independently associated with higher fracture risk. Although CKD is highly prevalent in the aging population, the interaction between these two conditions with respect to bone structure and mechanics is not well understood. The purpose of this study was to examine cortical porosity and mechanical properties in skeletally mature young and aging mice with CKD. CKD was induced by feeding 16-week and...