Repurposing the Hybrid Capture 2 (HC2) screening test for whole-genome sequencing of human papillomaviruses

Volume: 166, Issue: 12, Pages: 3421 - 3425
Published: Oct 7, 2021
Abstract
Simple and standardized approaches for genome analysis of human papillomavirus (HPV) by next-generation sequencing are needed. The aim of the study was to develop a protocol for direct deep sequencing of high-risk (hr) HPV strains, based on the widely used commercial Hybrid Capture 2 (QIAGEN) test, without any additional probe design. This protocol was applied to 15 HPV-positive and two HPV-negative cervical samples or cell lines and validated...
Paper Details
Title
Repurposing the Hybrid Capture 2 (HC2) screening test for whole-genome sequencing of human papillomaviruses
Published Date
Oct 7, 2021
Volume
166
Issue
12
Pages
3421 - 3425
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