Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
Abstract
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified determinants of this vaccine-induced adverse reaction. Super-resolution microscopy visualized vaccine components forming antigenic complexes with platelet factor 4 (PF4) on platelet surfaces to which...
Paper Details
Title
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
Published Date
Dec 2, 2021
Journal
Volume
138
Issue
22
Pages
2256 - 2268
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