Nickel-Catalyzed Reductive Cross-Coupling of Heteroaryl Chlorides and Aryl Chlorides

We report a nickel-catalyzed cross-electrophile coupling reaction of aryl chlorides and heteroaryl chlorides enabled by a synergistic combination consisting of halide effects and the addition of a magnesium salt. The reaction relies on the electronic difference between the aromatic and heteroaromatic coupling partners to afford the cross-coupled biaryl products using a single catalyst. A variety of heterocycles were amenable to the reaction, as...