Gene Therapy for Rhodopsin-associated Autosomal Dominant Retinitis Pigmentosa

Introduction Retinitis pigmentosa (RP) affects between 1 in 3000 and 1 in 4000 people and between 1.77 and 2.35 million people worldwide (https://rarediseases.org/rare-diseases/retinitis-pigmentosa/). The disease is characterized by the death of rod photoreceptor cells leading to defects in dark adaptation and night blindness. RP typically progresses to loss of peripheral vision and eventually to loss of central vision over a period of decades....