The Jury Is Still out on Placental Genes and Obstetric Complications.

Published on Sep 29, 2021in Schizophrenia Bulletin9.306
· DOI :10.1093/SCHBUL/SBAB117
Evangelos Vassos33
Estimated H-index: 33
(South London and Maudsley NHS Foundation Trust),
Robin M. Murray192
Estimated H-index: 192
('KCL': King's College London)
#1Cathy Davies ('KCL': King's College London)H-Index: 17
#2Giulia Segre ('KCL': King's College London)H-Index: 1
Last. Paolo Fusar-PoliH-Index: 98
view all 21 authors...
Summary Background Prenatal and perinatal insults are implicated in the aetiopathogenesis of psychotic disorders but the consistency and magnitude of their associations with psychosis have not been updated for nearly two decades. The aim of this systematic review and meta-analysis was to provide a comprehensive and up-to-date synthesis of the evidence on the association between prenatal or perinatal risk and protective factors and psychotic disorders. Methods In this systematic review and meta-a...
#3Qiang Chen (Johns Hopkins University)H-Index: 58
Defining the environmental context in which genes enhance disease susceptibility can provide insight into the pathogenesis of complex disorders. We report that the intra-uterine environment modulates the association of schizophrenia with genomic risk (in this study, genome-wide association study–derived polygenic risk scores (PRSs)). In independent samples from the United States, Italy, and Germany, the liability of schizophrenia explained by PRS is more than five times greater in the presence o...
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