Designing small molecules for therapeutic success: A contemporary perspective
Abstract
Successful small-molecule drug design requires a molecular target with inherent therapeutic potential and a molecule with the right properties to unlock its potential. Present-day drug design strategies have evolved to leave little room for improvement in drug-like properties. As a result, inadequate safety or efficacy associated with molecular targets now constitutes the primary cause of attrition in preclinical development through Phase II....
Paper Details
Title
Designing small molecules for therapeutic success: A contemporary perspective
Published Date
Feb 1, 2022
Journal
Volume
27
Issue
2
Pages
538 - 546
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