Shigella flexneri subverts host polarized exocytosis to enhance cell‐to‐cell spread

Volume: 116, Issue: 5, Pages: 1328 - 1346
Published: Oct 21, 2021
Abstract
Shigella flexneri is a gram-negative bacterial pathogen that causes dysentery. Critical for disease is the ability of Shigella to use an actin-based motility (ABM) process to spread between cells of the colonic epithelium. ABM transports bacteria to the periphery of host cells, allowing the formation of plasma membrane protrusions that mediate spread to adjacent cells. Here we demonstrate that efficient protrusion formation and cell-to-cell...
Paper Details
Title
Shigella flexneri subverts host polarized exocytosis to enhance cell‐to‐cell spread
Published Date
Oct 21, 2021
Volume
116
Issue
5
Pages
1328 - 1346
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