Nanoparticles: Promising Tools for the Treatment and Prevention of Myocardial Infarction.

Published on Oct 1, 2021in International Journal of Nanomedicine6.4
· DOI :10.2147/IJN.S328723
Qi Pan (Peking Union Medical College), Jing Xu1
Estimated H-index: 1
(Peking Union Medical College)
+ 3 AuthorsYue-Jin Yang (Peking Union Medical College)
Sources
Abstract
Despite several recent advances, current therapy and prevention strategies for myocardial infarction are far from satisfactory, owing to limitations in their applicability and treatment effects. Nanoparticles (NPs) enable the targeted and stable delivery of therapeutic compounds, enhance tissue engineering processes, and regulate the behaviour of transplants such as stem cells. Thus, NPs may be more effective than other mechanisms, and may minimize potential adverse effects. This review provides evidence for the view that function-oriented systems are more practical than traditional material-based systems; it also summarizes the latest advances in NP-based strategies for the treatment and prevention of myocardial infarction.
References219
Newest
#1Li-Li ZhangH-Index: 1
#2Yu-Yan XiongH-Index: 1
Last. Yue-Jin Yang (Peking Union Medical College)H-Index: 1
view all 3 authors...
Acute myocardial infarction (AMI) is an event of ischemic myocardial necrosis caused by acute coronary artery occlusion, which ultimately leads to a large loss of cardiomyocytes (CM). The prerequisite of salvaging ischemic myocardium and improving cardiac function of patients is to provide adequate blood perfusion in the infarcted area. Apart from reperfusion therapy, it is also urgent and imperative to promote angiogenesis. Recently, growing evidence based on promising pre-clinical data indicat...
Source
#1Youlu Chen (Peking Union Medical College)H-Index: 6
#2Yong Zeng (Capital Medical University)H-Index: 1
Last. Yongxiang Wei (Capital Medical University)H-Index: 1
view all 11 authors...
Abstract Compared with paclitaxel, sirolimus has been more used in the treatment of vascular restenosis gradually as an anti-proliferative drug, but few basic studies have elucidated its mechanism. The anti-proliferative effects of sirolimus or paclitaxel have been demonstrated by numerous studies under normoxia, but few studies have been achieved focusing hypoxia. In this study, porcine carotid artery injury model and classical cobalt chloride hypoxia cell model were established. Sirolimus nano...
Source
Background Vascular drug delivery becomes a promising direction in the development of novel therapeutic strategies in the treatment of cardiovascular pathologies, such as hypertension. However, targeted delivery of hydrophobic substances, with poor bioavailability, remains a challenge. Here, we described the hypotensive effects of a low dose of curcumin delivered to the vascular wall using hyaluronic acid-based nanocapsules. Methods The group of hypertensive TGR(m-Ren2)27 rats, was administrated...
Source
#1Chen-Jie LiuH-Index: 1
#2Li YaoH-Index: 1
Last. Bo-Tao ZhaoH-Index: 1
view all 4 authors...
Background Quercetin has potential value in treating cardiovascular diseases, but it is not suitable for clinical application due to its own water solubility. The limitation of quercetin can be distinctly ameliorated by delivering it with nanocarriers. Objective To determine the effect of quercetin-loaded mesoporous silica nanoparticles (Q-MSNs) on myocardial ischemia-reperfusion injury in rats and its mechanism. Methods Q-MSNs were synthesized, and the morphology of Q-MSNs and MSNs was characte...
Source
#1Moritz Mirna (University of Salzburg)H-Index: 5
#2Vera Paar (University of Salzburg)H-Index: 11
Last. Assoc. Prof. Michael Lichtenauer (University of Salzburg)H-Index: 1
view all 14 authors...
AIMS Myocarditis is associated with formidable symptoms and increased risk of adverse outcomes. Current approaches mostly rely on symptomatic treatments, warranting novel concepts for clinical practice. The aim of this study was to investigate the microRNA (miRNA) expression profile of Balb/c mice with experimental autoimmune myocarditis (EAM), choose a representative miRNA to antagonize after review of available literature and test its effects on myocardial inflammation in vitro and in vivo. ME...
Source
#1Pere Dosta (Georgia Institute of Technology)H-Index: 3
#2Catherine Demos (Georgia Institute of Technology)H-Index: 2
Last. Salvador BorrósH-Index: 32
view all 7 authors...
Purpose Endothelial cell (EC) dysfunction underlies the pathology of multiple disease conditions including cardiovascular and pulmonary diseases. Dysfunctional ECs have a distinctive gene expression profile compared to healthy ECs. RNAi therapy is a powerful therapeutic approach that can be used to silence multiple genes of interests simultaneously. However, the delivery of RNAi to ECs in vivo continues to be a major challenge. Here, we optimized a polymer formulation based on poly(β-amino ester...
Source
#1Jorge A Palma-Chavez (A&M: Texas A&M University)H-Index: 1
#2Kevin Fuentes (A&M: Texas A&M University)H-Index: 1
Last. Phapanin Charoenphol (A&M: Texas A&M University)H-Index: 9
view all 5 authors...
Vascular-targeted drug delivery remains an attractive platform for therapeutic and diagnostic interventions in human diseases. This work focuses on the development of a poly-lactic-co-glycolic-acid (PLGA)-based multistage delivery system (MDS). MDS consists of two stages: a micron-sized PLGA outer shell and encapsulated drug-loaded PLGA nanoparticles. Nanoparticles with average diameters of 76, 119, and 193 nm are successfully encapsulated into 3-6 µm MDS. Sustained in vitro release of nanoparti...
Source
#1Le-Chun Ou (HMU: Harbin Medical University)H-Index: 1
#2Shan Zhong (HMU: Harbin Medical University)H-Index: 1
Last. Jin-Wei Tian (HMU: Harbin Medical University)H-Index: 1
view all 4 authors...
Atherosclerosis (AS) is the main pathological cause of coronary heart disease (CHD). Current clinical interventions including statin drugs can effectively reduce acute myocardial infarction and stroke to some extent, but residual risk remains high. The current clinical treatment regimens are relatively effective for early atherosclerotic plaques and can even reverse their progression. However, the effectiveness of these treatments for advanced AS is not ideal, and advanced atherosclerotic plaque...
Source
#1Yu-Yan XiongH-Index: 5
#2Zhao-Ting GongH-Index: 1
Last. Yuejin YangH-Index: 45
view all 4 authors...
Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world, and the inflammatory response plays a pivotal role in the progress of myocardial necrosis and ventricular remodeling, dysfunction and heart failure after AMI. Therapies aimed at modulating immune response after AMI on a molecular and cellular basis are urgently needed. Exosomes are a type of extracellular vesicles which contain a large amount of biologically active substances, like lipids, nucleic acids...
Source
#1Devang R. AminH-Index: 1
#2Eric SinkH-Index: 1
Last. Brisa PeñaH-Index: 13
view all 6 authors...
End stage heart failure is a major cause of death in the US. At present, organ transplant and left-ventricular assist devices remain the only viable treatments for these patients. Cardiac tissue engineering presents the possibility of a new option. Nanomaterials such as gold nanorods (AuNRs) and carbon nanotubes (CNTs) present unique properties that are beneficial for cardiac tissue engineering approaches. In particular, these nanomaterials can modulate electrical conductivity, hardness, and rou...
Source
Cited By0
Newest
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.