Iridium-Catalyzed Redox-Neutral C2 and C3 Dual C–H Functionalization of Indoles with Nitrones toward 7H-Indolo[2,3-c]quinolines

An iridium-catalyzed redox-neutral C-2 and C-3 dual C-H functionalization of indoles with nitrones has been developed, furnishing a range of 7H-indolo[2,3-c]quinolines with high efficiency and regioselectivity under mild reaction conditions. Notably, sequential multiple C-H bond cleavage and C-C bond formation constitute the key events of this process, in which nitrone serves as a building block and an oxidant. Distinct from the previous methods...