RAF1MEK / ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation

Volume: 256, Issue: 1, Pages: 119 - 133
Published: Nov 16, 2021
Abstract
Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports have revealed that ameloblastoma harbours an oncogenic BRAFV600E mutation with mitogen-activated protein kinase (MAPK) pathway activation and described cases of ameloblastoma harbouring a BRAFV600E mutation in which patients were successfully treated with a BRAF inhibitor. Therefore, the MAPK pathway may be involved...
Paper Details
Title
RAF1MEK / ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation
Published Date
Nov 16, 2021
Volume
256
Issue
1
Pages
119 - 133
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