Characteristics of the Thrombus Formation in Transgenic Mice with Platelet-Targeted Factor VIII Expression
Abstract
Platelet-targeted FVIII gene therapy can efficiently recover bleeding phenotype for hemophilia A (HA), yet characteristics of thrombus formation with this ectopic expression of factor VIII (FVIII) in platelets remain unclear. Here, we generated 2bF8trans mice restrictively expressing human B-domain-deleted FVIII (hBDD FVIII) in platelets on a hemophilic (FVIIInull) mice background. The results showed no statistical difference in clot strength...
Paper Details
Title
Characteristics of the Thrombus Formation in Transgenic Mice with Platelet-Targeted Factor VIII Expression
Published Date
Sep 29, 2021
Journal
Volume
122
Issue
05
Pages
755 - 766
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