The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes

Volume: 237, Issue: 1, Pages: 301 - 312
Published: Oct 6, 2021
Abstract
The TCF7L2 protein is a key transcriptional effector of the Wnt/β-catenin signaling pathway, regulating gene expression. It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type 2 diabetes (T2D), implicating TCF7L2 and Wnt-signaling in metabolic disorders and homeostasis. In fact, TCF7L2-T2D variants confer the greatest relative risk for T2D, unquestionably predicting...
Paper Details
Title
The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes
Published Date
Oct 6, 2021
Volume
237
Issue
1
Pages
301 - 312
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