995P A pan-cancer analysis of KMT2D as a potential biomarker for immune checkpoint therapy
Abstract
Lysine methyltransferase 2D (KMT2D), which encodes a histone H3 lysine 4 methyltransferase, is one of the most frequently mutated genes in cancer patients. Previous studies showed that KMT2D-mutant tumor cell lines exhibited increasing immune infiltration and KMT2D mutation was correlated with higher tumor mutation burden (TMB) in multiple types of human cancers in TCGA datasets, suggesting that KMT2D-deficient tumors might be more sensitive to...
Paper Details
Title
995P A pan-cancer analysis of KMT2D as a potential biomarker for immune checkpoint therapy
Published Date
Sep 1, 2021
Journal
Volume
32
Pages
S847 - S847
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