Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats

Acute lung injury (ALI) exhibits the features of noncardiogenic pulmonary edema and acute inflammatory process, and it also displays significant morbidity and mortality rates. This work focused on identifying how overexpression of PPARγ coactivator 1α (PGC-1α) positively regulated TFEB and mitophagy for resisting the lipopolysaccharide (LPS)-mediated ALI. The levels of autophagic proteins and inflammatory factors in LPS-induced ALI rats and...