Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
Abstract
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH mutant or IDH wild-type gliomas to delineate sources of intratumoral heterogeneity. We showed that local DNA methylation disorder is associated with cell-cell DNA methylation differences, is...
Paper Details
Title
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
Published Date
Sep 30, 2021
Journal
Volume
53
Issue
10
Pages
1456 - 1468
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