HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA
Abstract
Human papillomavirus (HPV) DNA offers a convenient circulating tumor DNA (ctDNA) marker for HPV-associated malignancies, but current methods, such as digital PCR (dPCR), provide insufficient accuracy for clinical applications in patients with low disease burden. We asked whether a next-generation sequencing approach, HPV sequencing (HPV-seq), could provide quantitative and qualitative assessment of HPV ctDNA in low disease burden settings.We...
Paper Details
Title
HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA
Published Date
Sep 27, 2021
Journal
Volume
27
Issue
21
Pages
5857 - 5868
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