Biochemical characterization of tyrosine aminotransferase and enhancement of salidroside production by suppressing tyrosine aminotransferase in Rhodiola crenulata

• A tyrosine aminotransferase gene ( RcTAT ) was cloned from Rhodiola crenulata . • RcTAT catalyzes the formation of 4-hydroxyphenylpyruvate from tyrosine. • Suppression of RcTAT significantly enhances the salidroside production. Rhodiola crenulata is a traditional Tibetan medicinal plant mainly distributed in high altitude areas of Tibet. As the main extract of R. crenulata , salidroside has important medicinal activities in enhancing the...