Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments
Abstract
In our endeavors to develop potent anticancer agents, novel two series of 3,5-disubstituted-2-thiohydantoins 5a–c and the S-methyl counterparts 6a–c were designed and synthesized. The structural modifications were based on some reported thiohydantoins derivatives which showed promising antiproliferative activity. The activity of the compounds was verified via the in vitro cytotoxicity assay against prostate (PC-3) and breast (MCF-7) cancer cell...
Paper Details
Title
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments
Published Date
Feb 1, 2022
Volume
1249
Pages
131574 - 131574
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