Neutrophil Extracellular Traps-DNase Balance and Autoimmunity
Abstract
Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating bacteria and viruses. The accumulation of NETs in the circulation correlates with the formation of anti-double-stranded (ds) DNA antibodies and is considered a causative factor for systemic lupus erythematosus (SLE). The digestion of DNA by DNase1 and DNases1L3 is the rate- limiting factor for NET accumulation. Mutations occurring in one of these...
Paper Details
Title
Neutrophil Extracellular Traps-DNase Balance and Autoimmunity
Published Date
Oct 5, 2021
Journal
Volume
10
Issue
10
Pages
2667 - 2667
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Notes
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