Commentary: What Happens to the Aorta in Bicuspid Aortic Valve Disease?

Bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly and is characterized by genetic and hemodynamic factors that predispose affected individuals to aortic valve disease and aortopathies.1 Over half of patients with BAV will develop significant valvular dysfunction within 25 years of their initial diagnosis, for which the primary treatment is aortic valve replacement (AVR) for non-repairable valves.2 The past decade has...