431P The FOCUS4-N trial results and individual patient data meta-analysis (IPDM) of maintenance therapy versus active monitoring for patients with metastatic colorectal cancer (mCRC)

Optimising treatment strategies for patients with mCRC responding to first line chemotherapy has important connotations for quality of life, toxicity and prudent health care. Current standards in national guidelines support a strategy of ongoing chemotherapy until disease progression or excess toxicity. Trial level meta-analysis has indicated that complete treatment breaks may not detrimentally affect survival, however, breaks from treatment are...