Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate

Published on Jan 1, 2022in Magnetic Resonance in Medicine4.668
· DOI :10.1002/MRM.29042
Junjie Ma3
Estimated H-index: 3
(UTSW: University of Texas Southwestern Medical Center),
Craig R. Malloy75
Estimated H-index: 75
(UTSW: University of Texas Southwestern Medical Center)
+ 4 AuthorsJae Mo Park14
Estimated H-index: 14
(UTSW: University of Texas Southwestern Medical Center)
Sources
Abstract
PURPOSE Previous cardiac imaging studies using hyperpolarized (HP) [1-13 C]pyruvate were acquired at end-diastole (ED). Little is known about the interaction between cardiac cycle and metabolite content in the myocardium. In this study, we compared images of HP pyruvate and products at end-systole (ES) and ED. METHODS A dual-phase 13 C MRI sequence was implemented to acquire two sequential HP images within a single cardiac cycle at ES and ED during successive R-R intervals in an interleaved manner. Each healthy volunteer (N = 3) received two injections of HP [1-13 C]pyruvate for the dual-phase imaging on the short-axis and the vertical long-axis planes. Spatial distribution of HP 13 C metabolites at each cardiac phase was correlated to multiphase 1 H MRI to confirm the mechanical changes. Ratios of myocardial HP metabolites were compared between ES and ED. Segmental analysis was performed on the midcavity short-axis plane. RESULTS In addition to mechanical changes, metabolic profiles of the heart detected by HP [1-13 C]pyruvate differed between ES and ED. The myocardial signal of [13 C]bicarbonate relative to [1-13 C]lactate was significantly smaller at ED than the ratio at ES (p < .05), particularly in mid-anterior and mid-inferoseptal segments. The distinct metabolic profiles in the myocardium likely reflect the technical aspects of the imaging approach such as the coronary flow in addition to the cyclical changes in metabolism. CONCLUSION The study demonstrates that metabolic profiles of the heart, measured by HP [1-13 C]pyruvate, are affected by the cardiac cycle in which that the data are acquired.
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References28
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#1Junjie Ma (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
#2Jun Chen (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
Last. Jae Mo Park (UTD: University of Texas at Dallas)H-Index: 14
view all 10 authors...
PURPOSE Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as T2∗ s of the HP signals is critical. This study is to measure in vivo cardiac T2∗ s of HP [1-13 C]pyruvate and the products in rodents and humans. METHODS A dynamic 13 C multi-echo spiral imaging sequence that acquires [13 C]bicarbonate, [1-13 C]lactate, and [1-13 C]pyruv...
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#1Galen D. Reed (GE Healthcare)H-Index: 6
#2Junjie Ma (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
Last. Craig R. MalloyH-Index: 75
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PURPOSE This study aimed to investigate the role of regional f0 inhomogeneity in spiral hyperpolarized 13 C image quality and to develop measures to alleviate these effects. METHODS Field map correction of hyperpolarized 13 C cardiac imaging using spiral readouts was evaluated in healthy subjects. Spiral readouts with differing duration (26 and 45 ms) but similar resolution were compared with respect to off-resonance performance and image quality. An f0 map-based image correction based on the mu...
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#1Andrew AppsH-Index: 6
#4Andrew TylerH-Index: 2
Last. Damian J. TylerH-Index: 51
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#1Nadine Kawel-Boehm (University of Bern)H-Index: 13
#2Scott Hetzel (UW: University of Wisconsin-Madison)H-Index: 23
Last. David A. Bluemke (UW: University of Wisconsin-Madison)H-Index: 140
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Cardiovascular magnetic resonance (CMR) enables assessment and quantification of morphological and functional parameters of the heart, including chamber size and function, diameters of the aorta and pulmonary arteries, flow and myocardial relaxation times. Knowledge of reference ranges ("normal values") for quantitative CMR is crucial to interpretation of results and to distinguish normal from disease. Compared to the previous version of this review published in 2015, we present updated and expa...
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#1Jae Mo Park (UTSW: University of Texas Southwestern Medical Center)H-Index: 14
#2Galen D. Reed (GE Healthcare)H-Index: 6
Last. Vlad G. Zaha (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
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#1Oliver J Rider (University of Oxford)H-Index: 27
#2Andrew Apps (University of Oxford)H-Index: 6
Last. Damian J. Tyler (University of Oxford)H-Index: 51
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Rationale: The recent development of hyperpolarized 13C Magnetic Resonance Spectroscopy (MRS) has made it possible to measure cellular metabolism in vivo, in real time. Objective: By comparing part...
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PURPOSE: The purpose of this work was to study the contribution of liver [1-13 C]lactate to the lactate signal detected in the heart following injection of hyperpolarized [1-13 C]pyruvate. METHODS: A slice-selective saturation scheme was incorporated into a hybrid metabolic imaging and spectroscopy approach to selectively presaturate lactate in the liver. Imaging and slice-selective spectroscopy of [1-13 C]pyruvate and its downstream metabolites were sequentially interleaved in the same experime...
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#1Adam G. Goodwill (IU: Indiana University)H-Index: 23
#2Gregory M. Dick (Pomona College)H-Index: 31
Last. Johnathan D. Tune (IU: Indiana University)H-Index: 46
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: The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through multiple mechanisms that include extravascular compressive forces (tissue pressure), coronary perfusion pressure, myogenic, local metabolic, endothelial as well as neural and hormonal influences. While each of these determinants can have profound influence o...
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#1Jack J. Miller (University of Oxford)H-Index: 16
#2Lowri E. Cochlin (University of Oxford)H-Index: 19
Last. Damian J. Tyler (University of Oxford)H-Index: 51
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Purpose In vivo MRS is often characterized by a spectral signal-to-noise ratio (SNR) that varies highly between experiments. A common design for spectroscopic studies is to compare the ratio of two spectral peak amplitudes between groups, e.g. individual PCr/γ-ATP ratios in 31P-MRS. The uncertainty on this ratio is often neglected. We wished to explore this assumption. Theory The canonical theory for the propagation of uncertainty on the ratio of two spectral peaks and its incorporation in the F...
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#1Charles H. Cunningham (Sunnybrook Research Institute)H-Index: 31
#2Justin Y. C. Lau (U of T: University of Toronto)H-Index: 11
Last. Kim A. Connelly (St. Michael's GAA, Sligo)H-Index: 33
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Rationale: Altered cardiac energetics is known to play an important role in the progression towards heart failure. A non-invasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. Objective: To demonstrate the first hyperpolarized 13 C metabolic magnetic resonance imaging (MRI) of the human heart. Methods and Results: Four healthy subjects underwent conventional proton cardiac MRI follo...
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