Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers

Lesions of brain white matter (WM) and atrophy of brain gray matter (GM) are well-established surrogate parameters in multiple sclerosis (MS), but it is unclear how closely these parameters relate to each other.To assess across the whole cerebrum whether GM atrophy can be explained by lesions in connecting WM tracts.GM images of 600 patients with relapsing-remitting MS (women = 68%; median age = 33.0 years, median expanded disability status...