Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress

Volume: 218, Issue: 12
Published: Sep 29, 2021
Abstract
While phosphatidylinositide 3-kinase delta (PI3Kδ) plays a critical role in humoral immunity, the requirement for PI3Kδ signaling in plasma cells remains poorly understood. Here, we used a conditional mouse model of activated PI3Kδ syndrome (APDS), to interrogate the function of PI3Kδ in plasma cell biology. Mice expressing a PIK3CD gain-of-function mutation (aPIK3CD) in B cells generated increased numbers of memory B cells and mounted an...
Paper Details
Title
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress
Published Date
Sep 29, 2021
Volume
218
Issue
12
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