LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea
Abstract
Sensorineural hearing loss is mainly caused by irreversible damage to sensory hair cells (HCs). A subgroup of supporting cells (SCs) in the cochlea express leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a marker for tissue-resident stem cells. LGR5+ SCs could be used as an endogenous source of stem cells for regeneration of HCs to treat hearing loss. Here, we report long-term presence of LGR5+ SCs in the mature adult cochlea...
Paper Details
Title
LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea
Published Date
Oct 5, 2021
Volume
14
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