DeepCellState: An autoencoder-based framework for predicting cell type specific transcriptional states induced by drug treatment

Volume: 17, Issue: 10, Pages: e1009465 - e1009465
Published: Oct 5, 2021
Abstract
Drug treatment induces cell type specific transcriptional programs, and as the number of combinations of drugs and cell types grows, the cost for exhaustive screens measuring the transcriptional drug response becomes intractable. We developed DeepCellState, a deep learning autoencoder-based framework, for predicting the induced transcriptional state in a cell type after drug treatment, based on the drug response in another cell type. Training...
Paper Details
Title
DeepCellState: An autoencoder-based framework for predicting cell type specific transcriptional states induced by drug treatment
Published Date
Oct 5, 2021
Volume
17
Issue
10
Pages
e1009465 - e1009465
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