Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia

Volume: 14, Issue: 10
Published: Oct 1, 2021
Abstract
Background: The cellular mechanism of focal, idiopathic right ventricular outflow tract (RVOT) tachycardia is thought to be due to cAMP-mediated triggered activity. A potential molecular mechanism has not yet been determined. We identified and characterized a novel missense somatic mutation in the gene (GNAS) encoding the G s α (stimulatory G protein alpha-subunit) from a patient with RVOT tachycardia that is proposed to be the etiology of the...
Paper Details
Title
Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia
Published Date
Oct 1, 2021
Volume
14
Issue
10
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